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Antabuse

Antabuse is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.

Other names for this medication:
Chronol, Deadict, Diabuse, Disulfiram, Dulopam, Tyfusin, Ulfiram

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Also known as: Disulfiram

Description

Antabuse (disulfiram) blocks an enzyme that is involved in processing alcohol. Disulfiram produces very unpleasant side effects (such as fast heartbeat, chest pain, nausea, dizziness, flushing, and thirst) when combined with alcohol in the body.

Antabuse is used in certain people with chronic alcoholism. This medicine can help keep you from drinking because of the unpleasant side effects that will occur if you consume alcohol while taking Antabuse.

Antabuse is used together with therapy and counseling support to help you stop drinking. This medicine is not a cure for alcoholism.

Dosage

Take Antabuse exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You will need frequent blood tests to check your liver function.

Wear a medical alert tag or carry an ID card stating that you take Antabuse. Any medical care provider who treats you should know that you are using disulfiram.

When Antabuse is used as part of a treatment program for alcohol addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver. This is to make sure you are using the medicine as it was prescribed as part of your treatment.

Additional forms of counseling and/or monitoring may be recommended during treatment.

For best results, keep using this medicine as directed. Antabuse is sometimes given for up to several months or years.

Store at room temperature away from moisture, heat, and light.

Detailed Antabuse dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep in a tight light resistant container. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Antabuse are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Antabuse if you have consumed alcohol within the past 12 hours. Do not drink alcohol while taking disulfiram and for up to 14 days after you stop taking this medicine.

You should not use Antabuse if you are allergic to disulfiram, or if:

you have recently taken metronidazole (Flagyl) or paraldehyde; you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others). you have severe heart disease or blockage in the arteries of your heart; or you have been diagnosed with psychosis.

To make sure Antabuse is safe for you, tell your doctor if you have:

liver or kidney disease; heart disease, high blood pressure, history of heart attack or stroke; underactive thyroid; diabetes; seizures or epilepsy; head injury or brain damage; mental illness; an allergy to rubber; or if you take phenytoin (Dilantin), tuberculosis medicine, or a blood thinner (warfarin, Coumadin, Jantoven).

It is not known whether Antabuse will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether Antabuse passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medicine to anyone under 18 years old without medical advice.

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Inactivation of Cdc42 in radial glial cells resulted in hydrocephalus and ependymal cell denudation. Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. Risk factors of herpes zoster among children immunized with varicella vaccine: results from a nested case-control study. Further studies and development of appropriate instruments will bring minimally invasive spine surgery to a new era. As a4 KO mice were profoundly deaf and displayed enlarged endolymphatic fluid compartments mirroring the alterations in pendrin KO mice, we propose that pendrin and the proton pump co-operate in endolymph homeostasis. Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). A computational docking simulation of Cu/Zn-SOD and TFE (binding energy of Dock 6.3: -11.52 kcal/mol) suggested that THR37, ASP40, and GLU119, which are located near the active site, interact with TFE. Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes. Mechanisms underlying induction and progression of a neurogenic wave in the zebrafish developing retina.

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In addition, the Western blot analyses showed that, in response to stress, the levels of hippocampal pERK were reduced in the sham-operated controls, but not in the rats with BLA lesions. Analysis of 23 studies reporting epidemiological evidence on the joint relation. A cost effective simulator for education of ultrasound image interpretation and probe manipulation. Using this method, we screened 86 random genes on consecutive cosmids and identified functions for 13 new genes. Signals transduced through the TNF-alpha-TNF-RI-SIMPL pathway support hematopoietic progenitor cell survival, growth and differentiation. Following damage to skeletal muscle, satellite cells become activated, migrate towards the injured area, proliferate, and fuse with each other to form myotubes which finally mature into myofibers. In Case 2, fetal ultrasound study performed at 16 weeks of gestation disclosed skin infiltration. Initially, a large perimembranous VSD was repaired with a Dacron patch and after an uneventful vasotec blood pressure medication recovery of 1 week, he began to spike intermittent fevers from 38 degrees C to 39 degrees C. If a large amount of weight loss is not an easily achievable goal, other goals that might motivate people with obesity to adopt a healthy lifestyle should be considered.

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Retinal dystrophies associated with other mutations of the RLBP1 gene, including retinitis pigmentosa of Bothnia type, might account for a considerable number of cases of autosomal recessive retinitis pigmentosa in other geographic areas as well. Molecular cloning of Brugia malayi antigens for diagnosis of lymphatic filariasis. Two courses of the neo-adjuvant intraarterial chemotherapy were done. The classification of gastrograms by the location of the disease. Factors involved in the production of liposomes with a high-pressure homogenizer. Electron microscopy characterization reveals that the epitaxial growth develops from initial 3D islands to a high quality superlattice structure. Here, we used the estimated mean BMIs in a regression model to predict overweight and obesity prevalence by age, country, year, and sex. Laterally wedged insoles in knee osteoarthritis: do biomechanical effects decline after one month of wear?. We recommend additional studies with strong research designs to guide best practice in preparing YSHCN for adulthood.

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