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Ativan (Lorazepam)

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Ativan, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Ativan tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of Ativan. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

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Bactrim, Urispas, Lopid, Zovirax, Eriacta, Caverta, Uroxatral, Celexa, Benemid, Azitrox, Eriacta, Ketoco, Zolsoma, Lorpam, Fexodis, Lupimox, Tensiol, Isogest, Euroglip,

Also known as: Lorazepam


Ativan, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Ativan is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Ativan affects chemicals in the brain that may become unbalanced and cause anxiety. Ativan is used to treat anxiety disorders.

Ativan may be habit-forming and should be used only by the person it was prescribed for. Ativan should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.


When given intramuscularly, Ativan Injection, undiluted, should be injected deep in the muscle mass.

Injectable Ativan can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Ativan Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Ativan Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Ativan can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Ativan is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Ativan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Ativan should be avoided in people with:

Sleep apnea – Sleep apnea may be worsened by Ativan's central nervous system depressant effects. It may further reduce the patient's ability to protect his or her airway during sleep.

Myasthenia gravis – This condition is characterized by muscle weakness, so a muscle relaxant such as Ativan may exacerbate symptoms.

Pregnancy and breast feeding – Ativan belongs to the Food and Drug Administration (FDA) pregnancy category D, which means it is likely to cause harm to the developing baby, if taken during the first trimester of pregnancy. Evidence is inconclusive whether Ativan, if taken early in pregnancy, results in reduced intelligence, neurodevelopmental problems, physical malformations in cardiac or facial structure, or other malformations in some newborns. Ativan given to pregnant women antenatally may cause floppy infant syndrome in the neonate, or respiratory depression necessitating ventilation. Regular Ativan use during late pregnancy (the third trimester), carries a definite risk of benzodiazepine withdrawal syndrome in the neonate. Neonatal benzodiazepine withdrawal may include hypotonia, reluctance to suck, apneic spells, cyanosis, and impaired metabolic responses to cold stress. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth. Ativan may also inhibit fetal liver bilirubin glucuronidation, leading to neonatal jaundice. Ativan is present in breast milk, so caution must be exercised about breast feeding.

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The initial burst effect of the drug was to be controlled by the increase of concentration of chitin. Chronic consumption of alcohol during a longer period of time leads to the development of cirrhosis with the reduction in metabolic liver function and disorders in arginine metabolism. Massive picrotoxin therapy in treatment of acute barbiturate poisoning. The motoneurons are on average about 16 micron in diameter, are bipolar, and their dendrites have a transverse orientation. Remaining neck lymph node metastases were treated in principle by neck dissection. Multifactorial intervention from primary care is not effective in reducing falls or for reducing the severity of their consequences. These techniques include computed tomography (CT), magnetic resonance imaging, positron emission tomography/CT, single-photon emission CT (SPECT), and SPECT/CT. Dietitians of the 31 control patients continued to provide usual care.

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A novel model of in vitro osteocytogenesis induced by retinoic acid treatment. The purpose of this study was to elucidate the support system for cancer patients in the north area of Fukushima. The growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis is not only involved in brain growth, development and myelination, but also in brain plasticity as indexed by neurogenesis. We conclude that although the currently available HMG-CoA reductase inhibitors differ in their relative hypolipidemic effects, as a class they constitute the most effective agents available to maximally reduce elevated concentrations of LDL-cholesterol. Our objective was to compare outcomes of transperineal rectovaginal fistula repair performed in a single referral center on women with obstetric and nonobstetric causes. The choice of beam energy and the optimal design of these components was determined using GEANT4 and SRIM Monte Carlo simulations.

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The utility of allenyl and propargyl boronates for the propargylation of aldehydes and ketones mediated by zinc is presented. The anesthetic challenges continue to be the management of massive blood transfusion and prolonged anesthesia in small children, often further complicated by syndrome-specific issues. The fact that QUIN did not completely interact in accordance to its lipophilicity suggested that other factors also play a role in these interactions. In the tissue adjacent to the injury, trophic titers began to rise immediately after the lesion, reached a maximum 10 days later, and decayed thereafter. These ncRnAs are functional and are shown to be involved in diverse cellular activities.

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Fifteen minutes after creation of pneumoperitoneum, they were randomized to receive either VCV (Group V) or PCV (Group P). The question remains whether these memory and meta-memory effects are also present in (1) more near-life dynamic situations (i.e., using standardized videos) and (2) whether emotionality has an influence on memory and meta-memory deficits (i.e., response confidence) in schizophrenia compared to healthy controls. We investigated initial features of hepatic metastases from pancreatic cancer by examining the histologies of radiographically occult hepatic micrometastases. This newly formed bone was rapidly remodeled into compact cortical bone, which showed characteristic parameters of intact cortex 4 weeks after surgery. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.

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In this study we investigated the effect of activated clotting time level on the aortic cross-clamping triggers a systemic inflammatory response and it effects to lungs and heart. Different from traditional studies which focused either merely on the evaluation of different types of SVM or the voxel selection methods, we aimed to investigate the overall performance of linear and RBF SVM for fMRI classification together with voxel selection schemes on classification accuracy and time-consuming. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carried out in parallel with expression profiling of protein-coding genes. Disaggregatory effects of prostaglandin E1, amrinone and milrinone on platelet aggregation in human whole blood. We examined seasonality and winter seasonal affective disorder (SAD) in the Old Order Amish of Lancaster County, Pennsylvania, a unique population that prohibits use of network electric light in their homes. Cobinding of Pharmaceutical Compounds at Mineral Surfaces: Mechanistic Modeling of Binding and Cobinding of Nalidixic Acid and Niflumic Acid at Goethite Surfaces. The variance of the difference between MRIbased D90 and CT-based or fusion-based D90 was compared. In this study, we investigated the expression of RI and RII in 13 human non-small cell lung cancer cell lines (NSCLCs) and demonstrated decreased or loss of RII expression in five lung cancer cell lines, but not of RI. DNA loop formation between Nag repressor molecules bound to its two operator sites is necessary for repression of the nag regulon of Escherichia coli in vivo.

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Such distinct responses of expressions, especially positive expressions, play a central role in everyday social communication of humans and may give the responding individuals important advantages in cooperation and communication. Aortic regurgitant flow along the anterior mitral leaflet may have predisposed to mitral valve endocarditis, aneurysm formation, and its rupture. Renoprotective effect of Caralluma fimbriata against high-fat diet-induced oxidative stress in Wistar rats. However, early diagnosis of SSc is often difficult because the early clinical stages of the disease can be very similar to that of other autoimmune conditions. MFV in the CRA decreased with impaired central vision due to loss of both rod and cone function, had good test-retest repeatability, and may serve as a biomarker outcome to determine the potential physiological basis for improvements in RP clinical trials of therapies with indirect effects on blood flow to the retina. Radiation therapy in the treatment of female infertility and sterility, clinical experience versus experimental speculation. With potential design limitations, the NASA intervention program focusing on a high risk group may be associated to some degree, if not fully, with an overall cardiovascular risk profile improvement. Gibberellins (GAs) are phytohormones regulating various developmental processes in plants. Following the 12th wk of treatment the remaining mice were injected with the highly antigenic ultraviolet-induced, syngeneic tumor cell line UV5497-5. Participants were admitted to the hospital during the four study periods.

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Early gestational age at TO and maternal terbutaline administration adversely influenced lung growth in CDH-TO fetuses. Intensity modulated radiotherapy (IMRT) is a technique allowing dose escalation and normal tissue sparing for various cancer types. Nanoindentation was used to assess bone-tissue stiffness in three directions, and multiple linear regressions were used to calculate the correlation between collagen properties and bone-tissue stiffness, with the DMB as first predictor. Effect and removal mechanisms of 6 different washing agents for building wastes containing chromium. However, the use of fentanyl in combination with morphine and bupivacaine in elective caesarean section is debatable. Prospective studies are needed to determine whether routine testing to guide dosing is of benefit.

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Therefore, kinetic parameters of the epoxidation reaction were determined by following the rate of production of the diols. HIV-1 has evolved a protein, Rev, that participates in the export of unspliced / partially spliced viral RNAs from the nucleus. This is one of a handful of reported cases of anal sphincter disruption secondary to anal intercourse. The system described here may serve as a model for studying the the essential genes for differentiation of normal bone marrow cells. An infection with Mycoplasma synoviae that spread slowly within and among pens of chickens was observed in a brown-egg breeding population that had long been free of M. Comparative analysis of unconditioned and conditioned behavior of Wistar and prematurely aging OXYS rats revealed that the latter have significantly reduced locomotor and exploratory activities, increased anxiety in the elevated plus-maze test, spatial disorientation, and abnormal associative learning. Furthermore, CFA-injected BDR rats treated with RU 486 developed severe arthritis. How will pharmacogenetics impact the future of research and development?. The previous concept of serial connectivity of the neostriatum (funnel concept) has been replaced by the concept of parallel connectivity. The specimen is covered by a polyurethane soft block, in order to obtain a better image.

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One of the interesting and, so far, less explored avenues of such reactions is their potential for efficient, highly localized and controlled polymer production. We conducted calibration experiments and in situ measurements in the coastal Mediterranean Sea. Thus, PCV2 might induce autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis. The past decade has seen remarkable progress in clinical and basic cardiovascular research, and many areas of opportunity are promising. We searched 2 scientific databases: Medline (EBSCO) and Science Direct, for the years 1996 to 2011. A rare mechanism of resistance to colistin in Escherichia coli isolated from raw poultry meat. Malignant transformation in pilonidal disease is rare and never reported in Denmark. Hind feet with lower height differentials between claws had a lower incidence of lameness.

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Glucose for Children during Surgery: Pros, Cons, and Protocols: A Postgraduate Educational Review. These are the quality of life aspects that are considered to be basal and long term stabilizing from the perspective of dynamics of own self and they also systematically influence other aspects of quality of life which are derived from them. In the surroundings of the heme we found one substitution in the beta chains. The 16 bit programmable A/D conversion is completed with V/F convertor and programmable counter. vivax, strains in most of cyproheptadine periactin medicine the malaria endemic areas, rendering most anti-malarial ineffective. There are no reports of PARK2 microduplications in this population. Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis. Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA.

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These results suggest that xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval RBCs, but may not kill adult RBCs, presumably owing to PKC activation, as part of the mechanism for RBC switching. The results may partly be explained by the attenuated transmission of immuno-inflammatory signals to the brain. We have assessed the viability of a finger-prick capillary blood collection method to provide an alternative to venipuncture, assisting in the treatment of patients for whom venous sampling may be difficult to perform. The present prospective hospital-based study was conducted in Department of Radiation Oncology, University Teaching and Tertiary Referral Hospital. In docking studies antifilarials and chalcones exhibited demarcation in their binding affinity and modes.

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This study aimed to explore the anatomical and functional outcome of MH surgery at a tertiary eye care setting in Nepal. However, such kind of classifiers is actually built from a noisy negative set N as there can be unknown disease genes in N itself. The pattern seen at day 45 was identical to that observed in silver-exposed adults. Training doctors for family practice in primary health care work in Sri Lanka. Bioactivity of TNF-alpha was measured by cytotoxicity to L-929 cells and immunoreactivity by enzyme-linked immunosorbent assay (ELISA). In addition, the correspondence between the predicted shear stress distributions at the porous coating junction of partially coated devices and observed bone hypertrophy patterns that are apparently biased towards the medial aspect of the junction suggest that bone remodeling at the interface around porous coated hip implants may be initially stimulated by the development is it bad to take pepcid ac before drinking alcohol of small shear stresses. Initially the patient failed treatment with standard anticoagulation therapy with enoxaparin and warfarin. Agitation has traditionally been managed with chemical or physical restraint. To investigate the effectiveness of montelukast, a leukotriene receptor antagonist, in alleviating the symptoms of dysmenorrhea. PET can also portray the distribution of particle therapy by displaying activated species in situ.

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Seasonal changes in human sleep-wake rhythm in Antarctica and Japan. During the same period C2, A, D5 and D8 genotypes were also detected. The results showed differences between the perceived importance and the perceived met needs of family members. However, ROR alpha 1 and ROR alpha 2 display different binding specificities: ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROREs, whereas ROR alpha 2 recognizes ROREs with strict specificity and displays weaker transcriptional activity. In addition, anxiety-like behavior on the plus-maze correlated with intermittent EtOH intake in SI and GH rats. Restoration of photoreceptor outer segment after vitrectomy for retinal detachment. Moreover, the depletion of Bim overcomes apoptosis associated with Erk1/2 inactivation in UO126-treated leukemic cells, thereby establishing the contribution of Bim to drug-induced apoptosis. In conclusion, these findings may provide a new perspective of Polygonatum cyrtonema lectin (PCL) as a potential anti-tumor drug targeting PCD pathways for future cancer therapeutics. The technique is then applied to sparteine and debrisoquine data to resolve populations into distinct sub-groups. The identification of the target of isoniazid in the mycobacterial tuberculosis pathogen opens the way for the developoment of new drugs and diagnostic tests to combat drug-resistant pathogen strains.

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EFAM was technically achieved in an awake craniotomy patient and had good concordance with ECS mapping. Angiographic restenosis and its clinical impact after infrapopliteal angioplasty. The treatment is thought to suppress viral replication and induce viral clearance via immunomodulatory effects. The radon values in new ground-contact apartments are lower than in those built in the 1990s, apparently because of lesser soil gas intake into new buildings. Clinical sample studies were consistent with results from cell culture model systems showing that lung cancer cells with resistance to EGFR TKI and chemotherapy drugs contain significantly increased proportions of ALDH1A1-positive cells. A 32-year-old woman with deep infiltrating endometriosis involving the rectovaginal septum, the rectum, and the left ureter, complicated by silent left renal function loss. Maximal recovery of enzyme activity was obtained with an approximate 1:1 weight ratio of phosphatidylglycerol:phosphatidylcholine, with the observed rate being synergistic as compared to rates observed for each individual phospholipid. There are challenges to doing this, related to local barriers such as geography, AH training, workforce availability, scarce resources, an escalating number of patients requiring complex rehabilitation, and local knowledge. Evaluation of sample recovery efficiency for bacteriophage P22 on fomites. Finally, although there is currently limited clinical evidence, numerous extrapancreatic diseases and conditions that are highly prevalent in the general population may also be considered potential targets for PERT and related treatments.

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Method of pleural fluid drainage, categorized as VATS or chest tube placement. We revealed the structural features of particular synaptic regions, nidi, and newly found neurons, tasseled cells, in the main olfactory bulb (MOB) of the laboratory musk shrew (Suncus murinus). The following inhibition was fully antagonized by ketotifen (mast cell stabilizer), granisetron and ondansetron (5-HT3 antagonists), RP-67,580 (NK1 antagonist), and perivagal capsaicin pretreatment. Birthweight needs to be estimated with accuracy, and this article describes the efficiency of various ultrasound weight adalat 10 mg estimation formulae for small and large fetuses. The Patients as Partners Movement and the emerging health leader. The maximum likelihood method of estimation that was used takes into account all available information, though some of these observations may be incomplete due to a variable follow-up amongst the couples. Amount of oxygen absorbed by wine in the presence of potato oxidase.

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Our hypothesis is that a standard vocabulary will advance accuracy. Extensively drug-resistant tuberculosis (XDR-tuberculosis) is a global public health threat, but few data exist elucidating factors driving this epidemic. To reduce surgical waiting lists at the University of Alberta Hospitals. This study demonstrates that leptin and LEPR are more readily expressed in cancerous tissues suggesting a possible autocrine role in mammary carcinogenesis, which may be independent of hTERT and COX2 genes. Better compliance and better tolerance in relation to a well-conducted introduction to rub-in hand disinfection. Subinhibitory concentrations of antibiotics affect stress and virulence gene expression in Listeria monocytogenes and cause enhanced stress sensitivity but do not affect Caco-2 cell invasion. Therapeutic considerations in 22 case reports of frostbite of the extremities. The time of choice for repair of cleft palate in relation to the type of surgical repair and its effect on bony growth of the face. Optimal positioning for an adult athetoid cerebral palsy patient in a wheelchair. There is a paucity of data on community integration for older adults with schizophrenia.

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This method can be used in Epidemiology to estimate the incidence and prevalence of communicable and non-communicable diseases in a relatively inexpensive and quick way. We speculate that the PAP in our patients was related to the reduced quantity and/or to the altered quality of SP-B. RA-A47 was detected in the cultured medium of TNFalpha-treated HCS-2/8 cells and of IL-1-treated rabbit chondrocytes by Western blot analysis. There are little data regarding outcomes in patients with angina and severe coronary artery disease (CAD) treated with medical management. We showed that each type of binding molecule has a characteristic shallowness distribution. Participants were asked about treatment provision, their opinion of optimal treatment, and clinician confidence using both fixed and open response questions. In this supplement are given the characters of 41 new Salmonella serovars recognized in 1982 by WHO collaborating Centre for reference and research on Salmonella: 16 belong to the sub-genus I, 18 to the sub-genus II, 6 to the sub-genus III and 1 to the sub-genus IV. Greater London, England, people with advanced dementia (Functional Assessment Staging Scale 6e and above) from 14 nursing homes or their own homes. An engineering insight into the relationship of selective cytoskeletal impairment and biomechanics of HeLa cells. Estimates of nucleotide diversity per site varied greatly between polymorphic candidate genes (range: 0.0004-0.1295) and among species (range: 0.0024-0.0082), but were within the previously established ranges for conifers.

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Additionally plasma ADMA concentrations after 28 days of L-arginine supplementation significantly biaxin generic drug name exceeded initial concentrations. We found that H5N1 viruses from two of the three cloacal swabs rapidly replicated and caused severe structural damage to the infected NHBE cells within the early phase of infection. Patient-, treatment-, and facility-level structural characteristics associated with the receipt of preoperative lower extremity amputation rehabilitation. This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions. Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A. Triceratops is the most common dinosaur and isolated skulls contribute to a significant portion of this census. The accumulation of ALP mRNA was inhibited by both actinomycin D and cycloheximide, indicating that its induction is a complex event and may involve other regulatory proteins. At 3 months, the mean scores corresponded to low (DAS/DAS28) or moderate (CDAI/SDAI) disease activity.

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Both techniques (linear and patch) achieved good results with respect to mortality, functional status and survival. Moreover, monoubiquitylation, which does not signal degradation, has been found to be a key modification of many transcription factors and histones. Controlling for joint tenderness, the tender point count correlated with the degree of daily stress. The decision-making process of young adult women with cancer who considered fertility cryopreservation. We identified age-related changes in water-insoluble alpha-crystallin, the major membrane protein MP26 and the cytoskeletal proteins vimentin, phakinin and actin between control and UV-irradiated lenses. Children with HL were fitted with behind-the-ear hearing aids that had DNR technology. Si wafers implanted with either arsenic or boron at different fluences and implantation energies were used to compare SIMS with synchrotron radiation-induced GIXRF analysis. However, few have investigated the relationship between circulating microRNAs and obesity, which has become a major public health problem worldwide. Instead, in cells producing PulD and a permanently locked PulS-LolA dimer (in which LolA carries an R43L substitution that prevents lipoprotein transfer to LolB in the outer membrane), LolAR43L was found in the inner membrane, probably still associated with PulS bound to PulD that had been incorrectly targeted because of the LolAR43L substitution. Inhibition of human bone marrow fibroblast colony formation by leukemic cells.

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