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Bactrim (Trimethoprim)
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Bactrim

Bactrim is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly.

Other names for this medication:
Actrim, Bacin, Bacticel, Bactricid, Baktimol, Bascul, Bioprim, Canibioprim, Ciplin, Colizole, Comox, Cotribene, Cotrim, Cotrimol, Cotrimstada, Cotrix, Diseptyl, Doctrim, Drylin, Ectaprim, Eliprim, Esbesul, Escoprim, Gantrisin, Groseptol, Linaris, Megaset, Metoprim, Metoxiprim, Nopil, Novotrim, Qiftrim, Regtin, Resprim, Sanprima, Septrin, Sigaprim, Sinersul, Sulfoprima, Sutrim, Terbosulfa, Theraprim, Trimecor, Trimesulf, Trimethoprim, Trimol, Trimosul, Tripur, Trisul

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Also known as: Trimethoprim

Description

This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type). This medication should not be used in children less than 2 months of age due to the risk of serious side effects. This medication treats only certain types of infections. It will not work for viral infections (such as flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

Dosage

This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Bactrim DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.

Overdose

Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Bactrim DS dosage information

Side effects

The most common side effects associated with Bactrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Bactrim could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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The novel, genetically standardized GH transgenic mouse model is ideal for holistic transcriptome and proteome studies aiming at the identification of the molecular mechanisms underlying GH-induced pathological alterations especially in the kidney. Could our selection of module boundaries have potentially influenced our conclusions?. Clostridiaceae was the most abundant family throughout the gut, while Bacteroidaceae, Enterobacteriaceae, and Flavobacteriaceae also were well represented. A partially structured intermediate, with 1H/2H-exchange protection significantly less than that of the two isolated domains together, is detectable upon refolding the equilibrium-denatured scFv fragment. Examining neuronal network activity in freely behaving animals is advantageous for probing the function of the vertebrate central nervous system. The 150-mg dose of DMXB-A, compared with placebo, diminished the activity of the hippocampus during pursuit eye movements, but the 75-mg dose was ineffective. The cause of infertility in women with endometriosis is multifactorial. A novel missense mutation in lysosomal sulfamidase is the basis of MPS III A in a spontaneous mouse mutant.

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Acute severe exophthalmos in an infant with orbital capillary hemangioma. Symptom trajectories throughout two family therapy treatments for adolescent anorexia nervosa. Sall1 gene transfer induced marked neovascularization in rat cornea and in mouse embryoid bodies (EBs). The tricuspid E/E(a) ratio provides a reliable estimation of RV filling pressure and predicts cardiac events in patients with PAH. Non-synaptic inhibition between grouped neurons in an olfactory circuit. In this work we propose the first comparison of chromatographic-NMR and tests for assessment of column performance, to investigate to what measure the novel approach could provide an assay of the outcome of a given stationary phase without the need of packing the relative column. The estimated ED50 to suppress grooming behaviour in the open field were 1.75 mg/kg baclofen, 52 mg/kg barbital, 0.86 mg/kg clonazepam and 1.0 mg/kg THIP. This study evaluated behavioural and physiological (hormonal status, muscle structure) affects of prolonged ozone exposure in young females rats. Tooth replacement and tooth-to-tooth wear is more common than previously thought among heterodontosaurids, and in Heterodontosaurus the angle of tooth-to-tooth shear is shown to increase markedly during maturation.

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Transradial percutaneous coronary intervention for chronic total occlusion using sheathless technique and retrograde approach. PHI-like immunoreactivity has previously been demonstrated in a hypothalamic system with nerve endings in the median eminence, and, taken together, these findings suggest that PHI may represent a physiologic prolactin-releasing factor. The evolution of medicine is noticeable in most therapeutic areas, the worse the current therapeutic result, the more quick the improvement. A 42-year-old woman presented with cough and abnormal chest X-ray shadows. Relation of pyrogallol-peroxidative activity to isoniazid resistance in Mycobacterium tuberculosis.

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Arthroscopic examination showed complete absence of both cruciate ligaments in all three patients who had the combined sagittal laxity. Male quail in Experiment 1 did not copulate reliably with taxidermic models of females in a novel context, even though some of the subjects were allowed to copulate with female quail in their home cages. A 61-year-old woman was referred to our hospital with a mass in the left proglossis. Therefore, the application of international quality standards to forensic laboratories is of interest to, and must be understood by, not only scientists but also judicial authorities. Analysis of inhibitors and mutants showed that LPS-induced NO synthesis was mainly mediated by an arginine-utilizing source of NO generation. Plasma cortisol, end-tidal carbon dioxide, and the severity of 35 symptoms were measured at time points before and after the exposures.

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Recently, a variety of biological functions of natural dietary compounds derived from consumed foods and plants have been demonstrated in a number of studies. Ultrastructural assessment of liver and heart showed that vitamin A deficiency did not induce appreciable alterations in the morphology of their mitochondria. For the first time, the films based on polymer-stabilized cholesteric composites containing crown ether fragments with the optical properties sensitive to the complexation with potassium and barium ions were obtained. We present procedures of efficacy and safety testing for subretinal visual implants in humans, as developed during our pilot trial 2005 to 2009 and multi-centre clinical trial since 2010. The subjects were examined using the WAIS, Wechsler Memory Scale, Halstead-Reitan Neuropsychological Battery, Sickness Impact Profile, and Profile of Mood States. These models closely mimic the behavioural, electrophysiological, and pharmacological aspects of the human condition, with the epilepsy phenotype for both likely to have polygenic determinants. However, the oocytes with an intact corona radiata had a higher fertilization rate after conventional IVF insemination. Western blot studies confirmed that the exogenously applied NaHS increased eNOS but not nNOS protein expression in the rat CC.

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Results from real-time PCR assay also showed that propofol inhibited the mRNA gene expression of MMP-2, -7 and -9, and enhanced that of tissue inhibitor of metalloproteinase 1 (TIMP1) and TIMP2 in A549 cells. In two examples (Judd and Poggendorff illusions), we show that the perceptual centre of a set of points depends on how this centre is constructed. The appropriate dosage has to be adapted to the estimated lean body mass and, if necessary, reduced in a thin person, Digitoxin is preferentially used in cases with suspected renal insufficiency (especially in elderly patients). Fluoroaluminate pretreatment of mouse peritoneal cells potently reduced the cannabinoid response, while promoting arachidonate release on its own, consistent with earlier observations that this effect may be a receptor/G-protein-mediated process. Effects of phenyldiguanide (PDG) and capsaicin (CAP) were compared. The mitochondria of apicomplexan parasites provide much evidence of loss or change of function from analysis of mitochondrial protein genes. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. Factors associated with late presentation to HIV/AIDS care in South Wollo ZoneEthiopia: a case-control study. Data presented here suggest that the 4G/4G genotype is not a major risk factor in the aetiology of childhood ischemic stroke. In this review we discuss the application of epigenomics as a tool for biomarker research, with the focus on the analysis of DNA methylation in biofluids.

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CD34 was used to label the vascular endothelial cells and calculate the microvessel density (MVD). Rheumatologists urgently need education in this evolving field to be best positioned as contributors to care of such patients and investigators of the underlying mechanisms of these complications. Molecular biology of familial and sporadic vestibular schwannomas: implications for novel therapeutics. Laparoscopic cholecystectomy (LC) is the operation of choice in the treatment of symptomatic gallstone disease. For the last one decade, nanofluids have been a topic of intense research due to their enhanced thermal properties and possible heat transfer applications. Unlike trans p-tau, the cis cannot promote microtubule assembly, and is more resistant to dephosphorylation and degradation and more prone to aggregation. Our study aims to investigate the short-term and mid-term clinical results of Topping-off surgery in preventing adjacent segment degeneration when mild or moderate adjacent segment degeneration existed before surgery.

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The result was impressive and minimal bleeding loss during surgery was observed. In addition, reduction of phosphorylation of PDK1 substrates was demonstrated in vivo in mice bearing OCl-AML2 xenografts. Mud pack is a favorable option compared with hotpack for pain relief and for the improvement of functional conditions in treating patients with knee osteoarthritis. In the present study the effect of cilostazol on blood flow and interstitial adenosine concentration was compared with that of the PDE3 inhibitor, milrinone, and the adenosine uptake inhibitor, draflazine. Prospective study in surgical reanimation at the University Hospital of Rouen over 9 months (November 2007-September 2008). The Return of the Vulnerable Plaque: Optical Coherence Tomography Imaging of a Case of a Late In-Stent Restenotic Chronic Total Occlusion. Good immediate results have been well documented when stapedotomy or stapedectomy are chosen. A morphological study of the effect of reserpine on the avian adrenal medulla. Finally in the remaining 4 patients, ASD closure was obtained by completely re-orienting the system with a jugular approach. Finally, in paediatric settings with endemic malaria, adding haemoglobin level to the SATS discriminator list may help to improve the undertriage of patients with malaria.

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The challenges and constraints within the Czech and UK health-care systems preventing delivery of palliative care to all patients with palliative care needs will be identified. Exploring our origins--the importance of OriL in mtDNA maintenance and replication. Trade groups ask for delay in implementation of PPS refinements. Interestingly, Tat immune complexes also blocked neurotoxicity caused by NMDA receptor agonists but not kainate/AMPA receptor agonists. To date, patient interface has been shown to have little effect with respect to delivered dose, but some may provide advantage with respect to ease of use and patient acceptance. The patients were treated using teletherapy 50 Gy/25 fractions, five fractions per week to the whole pelvis together with HDR Cobalt -60 afterloading brachytherapy of 850 cGy/fraction, weekly to point A for 2 fractions. We classify studies as addressing questions at different levels or linking different levels, i.e. Rotational IMRT techniques compared to fixed gantry IMRT and tomotherapy: multi-institutional planning study for head-and-neck cases. Knowledge of fertility and ART as measured by the male version of the Fertility Awareness Survey.

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For many years, medications have been available and used in adult populations to treat dyslipidemia. ICH was chosen as an Emergency Neurological Life Support (ENLS) protocol because intervention within the first hours may improve outcome, and it is critical to have site-specific protocols to drive care quickly and efficiently. Aberrant synapse formation has been implicated in development and propagation of epileptic potential. Culturally and linguistically appropriate Spanish language materials need to be developed or made more widely available to train workers. In a model system with sterile soil amended with laboratory cultures of oxalotrophic bacteria and fungi, the addition of calcium oxalate induced a distinct pH shift and led to the final precipitation of calcite.

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However, in the western boundary currents and eddy-rich regions, the warmer surface waters compared to surrounding waters enhance upward heat release-a positive correlation between upward heat release and surface ocean temperature, implying that the ocean drives the atmosphere. Progression was determined by the Response Evaluation Criteria in Solid Tumors version 1.1. Self-assembling peptide nanofiber scaffolds have been studied extensively as biological materials for 3-dimensional cell culture and repairing tissue defects in animals. Factors associated with pulmonary tuberculosis among patients seeking medical attention at referral clinics for tuberculosis. Liver transplantation is the best treatment for end stage liver diseases. We have earlier reported an automatic method to estimate aponeurosis orientation based on Gabor transform and seroquel drug class Revoting Hough Transform (RVHT). To identify the possible association between dental caries and body mass index (BMI) and to explore the effect of BMI on tooth eruption in a cohort of elementary schoolchildren. Brain damage following Urokon injection in the brachial artery: report of a case. Real-Time Metabolic Interactions between Two Bacterial Species Using a Carbon-Based pH Microsensor as a Scanning Electrochemical Microscopy Probe. Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance.

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Field evaluation of flunixin meglumine in the supportive treatment of ovine mastitis. Further studies are needed to clarify causality and assess feasibility of interventional studies to preserve body mass in aging men. Small angle X-ray diffraction patterns showed that OREC was intercalated by chitosan. In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy. At 6 hours, these same doses of phenylpropanolamine produced little or no change in either parameter. Eosinophilic esophagitis (EE) is an increasingly recognized primary clinicopathologic disorder of the esophagus which lacks a specific etiology. Palliative care clinicians have access to detailed personal and family history during a highly vulnerable transition. The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells. In people with IGT, dietary change to ensure weight loss, coupled with physical activity, is clinically effective and cost-effective in flagyl alcohol reaction reducing progression to diabetes. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens.

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Lactobacilli predominant in the gastrointestinal tract of the adult swine. Study 1 included the assigned questionnaires and weekly diaries. To investigate the effects and mechanism of pharmacological ascorbate against Influenza A/CA/7/09 (H1N12009). In addition, elevated concentrations of hsp70 alone could not significantly inhibit induction of the DNA-binding activity of endogenous HSF in cultured rat cells, and the induction was also not inhibited in cultured rat cells or Drosophila cells containing elevated levels of all members of the heat shock protein family. We report that PRC2 activity is regulated by the density of its substrate nucleosome arrays. Two groups with three sub-groups in the first group of S-type lipopolysaccharides can be classified based on the electrophoretic profiles. A pair of correlated event times may be observed for each patient, time to development of cirrhosis and time to referral to a cohort. They are divided into 3 groups: 14 patients undergoing resection of ileocecal junction (RUIC), 7 to total colectomy (CT) and 10 to distal colectomy (CD). Enhanced dehydroepiandrosterone synthesis by amnion compared to chorion: a comparative study using the reverse-isotope dilution technique.

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Anomia is a language abnormality frequently found in such cases, and other language deficits are rarely described. To identify factors that influence the translation of evidence-based injury prevention interventions into practice in community sport, and to provide specific evidence for the effectiveness of an evidence-based exercise training programme for lower limb injury prevention in community Australian football. Twenty patients with adrenal incidentaloma underwent laparoscopic adrenalectomy for SCS, whereas 15 were amiloride suspension managed conservatively. Inspite of the advantages of these materials, certain complications has been experienced in our study with regard to the resorption and degradation of the material which has been mentioned and explained in our article. Active sequences were uncovered in several marine organisms, two nematodes, an arthropod, a bacterium, and an insect virus, often in multiple sequence families and copies. This could be identified on a CT brain-perfusion study based on characteristic venous time-density curves.

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Finally, propagation experiments revealed that barks propagate at greater distances over water surface than over ice, acoustic features such as frequency modulation and frequency spectrum being highly resistant to degradation during propagation. Our data demonstrates a very high S100B expression in white matter tracts, in particular in human corpus callosum. We examined the assembly processes of the capsid proteins of canine parvovirus (CPV) in mammalian and insect cells. Haemocytes from Crassostrea gigas and OsHV-1: A promising in vitro system to study host/virus interactions. Computed tomography revealed two lesions located in the occipital and left temporal area of the brain. For married households, we find a small effect (about 2-3 percentage points) from being in the lowest of five self-reported health categories. The induction of monocyte chemoattractant protein-1 mRNA in Schwann cells treated with tumour necrosis factor-alpha was reduced by inhibitors of nuclear factor-kappa B and the p38 mitogen-activated protein kinase.

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Ocular disorders as the prevailing manifestations of antiphospholipid syndrome: a case series. We present a prospective study that evaluated the efficacy of low-cost, technology-based intervention approaches in high neurontin 300 mg street price schools to enhance the use of hearing protection among adolescent farmworkers. In contrast, the substitution P89R in GSTU2 does not modify the reactivation yield and does not impair the affinity of the mutant for glutathione, suggesting that all three residues investigated in this work are fundamental in the creation of enzymes characterized by unique biochemical properties. Lamotrigine for central poststroke pain: a randomized controlled trial. Good control of X(T) at near range may preclude early examinations. Attitude toward ODT is favorable in a high percentage of students of journalism. Previously, we showed that EMAP II is an essential mediator of cigarette smoke-induced lung emphysema in mice linking endothelial cell apoptosis with inflammation. There are speculations that GH has become widely used as a performance enhancing drug among athletes of various sports. Adaptive schemes applied to online SVM for BCI data classification.

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