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Cozaar (Losartan)

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Cozaar belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
Angioten, Aratan, Cartan, Corus, Czartan, Enromic, Forzaar, Giovax, Gitox, Insaar, Loctenk, Lopress, Losacar, Losap, Losapot, Losapres, Losarb, Losartas, Losatan, Losazid, Losazide, Lostad, Lostan, Lotar, Loxibin, Lozap, Mozartan, Ostan, Prelow, Psycholanz, Rasertan, Rasoltan, Resilo, Sanipresin, Sarilen, Sarlo, Sartens, Sedeten, Simperten, Tanlozid, Temisartan, Tiasar, Xartan, Zaart

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Also known as: Losartan


Cozaar is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management

Cozaar is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients

Cozaar is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension. In this population, Cozaar reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Cozaar dosage information


If you overdose Cozaar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cozaar overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cozaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Cozaar if you are allergic to losartan.

Do not use Cozaar if you are pregnant, and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

To make sure Cozaar is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; an electrolyte imbalance (such as high levels of potassium in your blood); if you are on a low-salt diet; or if you are dehydrated.

You should not breast-feed while using Cozaar.

Cozaar is not approved for use by anyone younger than 6 years old.

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Hepatotoxicity and metabolism of acetaminophen in male and female rats. Ways of differentiating these lesions from other renal masses are discussed. MRI of male athletes with an acute hamstring injury was obtained within 5 days of injury. Use of coronary CT angiography in the diagnosis of patients with suspected coronary artery disease: findings and clinical indications. Objectives of the teaching of anatomy/embryology in medical curricula in The Netherlands. Once antegrade access was secured, catheters were placed in a conventional fashion. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM.

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The Rorschach and diagnosis of neurotic conditions in children and adolescents: a case study. A comprehensive European diabetes educational toolbox is aimed to be published and continuously updated on the SWEET website. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Besides their potent regulatory role on GH release, its endocrine actions are highlighted by SST/CORT and ghrelin influence on insulin secretion, glucose homeostasis, and insulin resistance. This systematic review examines the available cardiovascular risk reduction data for the surgical treatment of OSA. The progenitors were integrated into the host urethral sphincter and the host cell differentiation was stimulated in vivo.

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Breathing exercises as an adjunct in the treatment of bronchial asthma and pulmonary emphysema. Effects of dietary zinc on melanoma growth and experimental metastasis. Radiologic treatment of carcinoma of the uterine cervix and fundus. Bridges between spermatocytes and spermatids exhibit species specificity with regard to size, structure and density of the electron dense bridge substance. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C from the simple eukaryote Saccharomyces cerevisiae. To assess the effect of different embolic agents in curing craniofacial tumors and vascular diseases, 21 patients who were treated by intra-arterial embolization were divided into three groups: gelfoams, bletilla striatas and coils. The experimental findings and model tests show that the force coordination patterns are adapted based on the principle of minimizing muscle force output that is coefficient dependent rather than on the principle of minimizing signal-dependent variance.

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Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil. We find that these theories point to a limited range of situations in which autists should not be blamed for transgressive actions for which neurotypical individuals should be blamed. The results show that lymphocytotoxic titers (NIH-test) do not predict the outcome of in vivo effectiveness of ATG in rhesus monkeys. Despite the absence of obvious sequence homology between several subunits, detailed analysis of sub-complexes strongly suggests analogy between subunits of the two complexes. Quorum sensing and density-dependent dispersal in an aquatic model system. We report a patient with epidural abscess, vertebral osteomyelitis and discitis in the cervical spine that was caused by iatrogenic perforation of the pharynx during diagnostic oesophagoscopy, which has not been recorded previously in the literature. Four phosphorylation sites (position 24 (serine), 32 (serine), 34 (threonine) and 36 (tyrosine)) were identified for tear lipocalin using this method. Leptospirosis is the most prevalent zoonosis affecting more than 1 million populations worldwide. The significance of this finding and its possible role in the pathogenesis of inflammatory arthritides are discussed. Blood and milk (mammary secretion) samples were collected on the last 5 d before and on d 1, 3, 5, 7, 10, and 14 after the last milking.

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Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements. We conducted an extensive clinical, hormonal and functional study in 20 patients carrying the expansion of the polyalanine tract of FOXL2 associated with BPES. The level of bacterial growth along the water/dialysis fluid pathway, and the effect of in-line bacterial filters, on colony counts in reverse osmosis reject water and monitor effluent were examined. Higher expenditure per police officer is associated with a lower fatality rate. The present study was designed to analyze the cardio-toxic side effect of Li and the ability of grape seed and skin extract (GSSE) to protect the heart against such toxicity. Patients with secondary causes, an inflammatory abdominal aortic aneurysm, and immunoglobulin G4-associated idiopathic retroperitoneal fibrosis were excluded. Dysphagia, cognitive impairment, and malnutrition directly and indirectly decreased ADL in elderly people living at home and receiving home nursing care. We have demonstrated that the quantification limits of many drugs measured by LC-MS/MS are low enough to allow estimation of their pharmacokinetic parameters following administration of a microdose. Echocardiographic evidence for increased cardiac performance during early renal hypertension in metoclopramide dose cats dogs.

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