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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

Take Cytoxan tablets by mouth. Swallow Cytoxan with water. Take your doses at regular intervals. If you want to achieve most effective results do not stop taking Cytoxan suddenly.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature at or below 25 degrees C (77 degrees F) away from moisture and heat. This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.

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The objectives of our study were to (i) determine deer ked infestation prevalence and intensity on moose and (ii) evaluate if habitat characteristics and moose population density are determinants of deer ked abundance on moose. Moreover, the emergent role of renal pericytes in vessel rarefication during fibrosis promises to reveal novel therapeutic targets to counteract devascularization, disease progression and loss of kidney function. Two isoenzymes of 11beta-HSD have been characterized and cloned in human tissues. Synapses made by parvalbumin-negative terminals showed five times more immunoreactivity for the alpha(2) subunit than synapses made by parvalbumin-positive basket cells, whose synapses were frequently immunonegative. SORE MOUTH, purpura, weight loss, hepatomegaly, peripheral neuritis and monocytosis. Concurrently, several low molecular weight components (17 to 65 kd) appear or become increasingly accessible to 125I. Urinary N-acetyl-beta-D-glucosaminidase (NAG), a sensitive marker for renal damage, was much higher in male beagles than in females.

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Prohibitins form large ring complexes in the inner membrane that are composed of PHB1 and PHB2 subunits and are thought to function as membrane scaffolds. Gestational age at delivery, neonatal biometry, neonatal condition at birth. Among, various Green House Gasses (GHGs), CO2 occupies the first position in anthroposphere and has detrimental effects on the ecosystem. Dependent on the results, flexible endoscopic or video fluoroscopic evaluation of swallowing has to be performed so that indications for enteral or oral feeding can be made. Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?. Normal prediction equations were generated based on stature, body mass index (BMI), age, and sex as independent variables and then used in between-group comparisons. Determination of the minimum measurement time for estimating long-term mean radon concentration. In addition, we checked conference proceedings, reference lists, and contacted authors.

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Reduction and temporary stabilization of acetabular fractures using ASIF mandibular reduction forceps: technique and results using plate fixation in 25 dogs. We also show that the evidence in this model can represent either log likelihoods, log-likelihood ratios, or log odds, all leading proposals for the cortical processing of sensory data. Viral RNA synthesis is directed by the virus-encoded RNA dependent-RNA polymerase (L protein) and requires viral RNA encapsidation by the Nucleoprotein. Luminal flow stimulates NO production by nitric oxide synthase type 3 and its translocation to the apical membrane in medullary thick ascending limbs. We created a system that allows the visualization of breath sounds (visual stethoscope).

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These PL1/CTAT mixtures exhibited an improved elastic character (as determined by dynamic rheometry) that translated in a much longer value of the cross-over relaxation time and a pronounced thixotropic behavior which are indicative of a strong intermolecular interaction. Progressive implementation of multiple quality improvement strategies predominately directed at individuals and clinical teams (guideline development and dissemination, education, clinical audit, encouragement of multidisciplinary team working, task sinequan dose redesign). An advanced method of measuring and analyzing electrophoretic mobility profiles (electrophoretic fingerprints) was developed and for the first time applied to the cell surface. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. The present study investigated a protective effect of HSP90 inhibitors observed in cultured OPCs. The results of the present study demonstrated that spinal morphine was capable of suppressing the evoked activity of the viscero-somatic convergent neurons, resulting in suppression visceral and somatic pain behavioral reflexes. Receptor involvement was investigated using an anti-receptor for advanced glycation end products (anti-RAGE)-blocking antibody, soluble RAGE, or Toll-like receptor 4 (TLR-4)-deficient osteoclast precursors. In addition, crystal-induced arthritis and inflammatory osteoarthritis may be difficult to distinguish from EORA. The present review provides an overview of the current literature on the prevention and treatment of PCME.

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Exposure of adult rat cardiomyocytes to low levels of DOX for 48h induced apoptosis. Effect of a Swelling Agent on the Performance of Ni/Porous Silica Catalyst for CH4-CO2 Reforming. Climbing phenomenon, a cultural species and type sign of Mycobacteria tuberculosis. The aim of this study was to clarify relationships between participation in community activities and psychosocial and physical health of community tenormin blood pressure medicine -dwelling elderly. Contextualizing exposures and experiences of behaviors that influence the risk of crash injury in latino adolescent males. Tensile bond strength of sealants following Er:YAG laser etching compared to acid etching in permanent teeth. However, open CS was reported to have relatively high incidences of wound complications. The most common pathogenic bacterium is Nocardia asteroids, which is frequently associated with disseminated lesions.

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In this study, combined treatment with GEM and AgNPs significantly inhibited viability and proliferation in A2780 cells. Bu-2743E, a leucine aminopeptidase inhibitor, produced by Bacillus circulans. We found increased MIF mRNA levels in the lungs and MIF protein levels in the serum of infected mice. The plasmodium of the myxomycete Didymium bahiense was cultured on oatmeal agar plates in a laboratory. This study will serve as a reference point in monitoring different types of physical activities and implementing public physical activity policies in developing countries. miR-93 expression reduced the expression of pro-inflammatory factors in BV2 cells. In vitro transcription of mutated Leishmania tarentolae spliced leader RNA genes approximates in vivo patterns. The one year follow-up revealed no signs of recurrent tumour or metastases. Given the vitality of Lactobacillus in human health, recognition and isolation of the species producing compound in antagonist to the pathogens existing in the food products can be a helpful and effective step toward maintaining the valuable native Lactobacillus and using them in the dairy industries. Blacks have disproportionately high rates of cardiovascular disease.

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124.5/1,000 patients) were also greater for whites than for blacks, with a relative odds ratio of 1.53. Validation studies of the Portuguese experimental version of the Montreal Cognitive Assessment (MoCA): confirmatory factor analysis. Immunological studies of the chemical characteristics of hemoglobin and its derivatives. Psychotic depression--beyond the antidepressant/antipsychotic combination. Dogs with clinical signs showed lower relative and absolute values of B lymphocytes than dogs without clinical signs, although the differences were not statistically significant. Fabrication of mesoporous silica/polymer composites through solvent evaporation process and investigation of their excellent low thermal expansion property.

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Monopolar electrical stimulation threshold for intraoperative motor cortical mapping were more consistent in the upper limb compared to lower limb and facial muscles. Biochemical and molecular studies of mitochondrial function in diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. Mesh-related complications may frequently occur more than 2 years after the primary operation. Recently, the acceleration (and retardation) of blood vessel growth has been an increasingly frequent subject of study. The different members of this family of plant proteins show both sequence and structural homology, and are toxic to bacteria, fungi, yeasts and various naked cells in vitro. The two apparently identical nuclei presumably carry the same chromosomes but the number of different chromosomes in the organism is unknown. More importantly, this increase can first be detected in premalignant lesions in some of these tissues. Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy. Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence. A multidisciplinary approach can be useful, although in clinical practice the selection of patients suspected of having IgG4-RKD is critical in the cases presenting with a renal mass that mimics malignancy.

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The results showed that different expression patters of Ikaros and Helios isoforms existed in leukemia patients, that is, Ikaros isoform (Ik-6) was predominantly expressed in acute lymphoblastic leukemia (ALL) with BCR/ABL fusion gene, while Helios isoform (He-i) was glimepiride tab 2mg overexpressed in T-cell ALL patients. A very remarkable concentration ratio of doxepin:desmethyldoxepin was observed in myocardial tissues. Recently, we have reported that LPA(3) indicated opposite effects on cell migration, depending on the cell types. Bubbles in the belly: imaging of cystic mesenteric or omental masses. The external sphincter appears more important for continence after radical prostatectomy. Critical to determining the risks or benefits from these products are valid human clinical trial PREP assessment methods. In this work, structural changes in 2-fluorocyclohexanone were theoretically studied with the aim at finding intramolecular interactions that induce the conformational equilibrium towards the axial or equatorial conformer. Often, the resources are not only limited but improperly utilized. We unexpectedly found that both the intranuclear and cytoplasmic patterns of expression depended on the prior history of sound stimulation. These results suggest that a direct neural connection of the intermediate LS to the PAG has an inhibitory role in regulating lordosis in male rats.

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Treatment of ICUE includes a diet trial of gluten restriction and consideration of early surgery because of the potential for associated malignancies. Electron microscopic studies on the sinusoidal cells in the monkey liver. This is the first epidemiological study to operationalize the recently published diagnostic criteria for MBI and determine prevalence estimates across the spectrum from cognitively normal to MCI. A behavioral measure of explicit memory performance was positively correlated with the change in amygdala connectivity within a neighboring region in the superior frontal gyrus. Invariant natural killer T (iNKT) cells have evolved to recognize CD1d-presented lipid antigens and are known to play important roles during infection with bacterial, viral, protozoan, and fungal pathogens. A systematic evaluation procedure was developed to assess concurrent and predictive validity, repeatability, and aspects related to utility. The aim of this study was to examine the markers of pro-coagulation response and VTE risk in an exemplar multimodal model of pre-operative combination chemotherapy and radiation therapy, followed by complex cancer surgery.

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