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Daklinza (Daclatasvir)
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Daklinza

Daklinza is a medication used in combination with other medications to treat hepatitis C. Daklinza is only available as a brand name drug. The other medications used in combination include sofosbuvir, Daklinza, and interferon, vary depending on the virus type and whether the person has cirrhosis.

Other names for this medication:
Daclatasvir

Similar Products:
Revia, Antabuse, Alprostadil, Xeloda, Sildigra, Luvox, Ranisun, Dipyridamole, Opidol, Ocifril, Glibact,

Also known as: Daclatasvir

Description

Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

Daklinza is used in combination with other medications to treat chronic hepatitis C in adults.

Daklinza treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Daklinza must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

Daklinza is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the Zyclara® cream pump upright.

Detailed Daklinza dosage information

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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Predictors of smoking cessation in Taiwan: using the theory of planned behavior. A large fluid accumulation in the thoracic cavity was observed, along with an increase in hematocrit and body weight and a decrease in serum albumin. Clinical features of toxoplasmic retinochoroiditis in patients with acquired immunodeficiency syndrome. After orthodontic treatment, the upper dental arches were expanded, and the teeth were alined regularly, which provided good conditions for alveolar bone grafting. Organotypic cultures provide a more in vivo-like epidermal tissue and may therefore respond in a different manner than previous culture models in which epidermal differentiation is incomplete. Infusion of saline attenuates the decrease in renal function induced by radiographic contrast agents among patients with chronic renal insufficiency. The symbiotic nitrogen fixing legumes play an essential role in sustainable agriculture. A total of 5 ml venous blood sample was collected from each participant. The solution of the equation gives a chain structure with an infinite number of circuit loops in which each of them is only composed of four neurons. The function of the foot depends on attaining a stable position beneath the tibia.

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Prevalence and perceived health effect of alcohol use among male undergraduate students in Owerri, South-East Nigeria: a descriptive cross-sectional study. This strategy has the advantage of maintaining both structure and functions, albeit with increased acute and delayed side effects. The role of health and physical activity in the adoption of innovative land use policy: findings from surveys of local governments. However, many active games are exercise themed, which may interfere with the distracting properties that make game-based exercise more enjoyable than traditional exercise. Minireview: applications of next-generation sequencing on studies of nuclear receptor regulation and function. The patients were grouped into (a) patients/sinuses with MRCs (test), and (b) patients/sinuses with healthy or any other changes (control) for further comparison and evaluation. Protease activated receptors (PARs) form the molecular link between coagulation and inflammation. There was also suggestive evidence that penetrating brain injury may exacerbate the cognitive effects of normal aging. Importantly, we further confirmed that EMT and the Notch signaling pathway were inactivated in CRC cells after FOXD2-AS1 knockdown.

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The CURLIE reconstruction combined with SEPG fitting enables accurate T2 estimation from highly undersampled multi-echo spin-echo radial data thus, yielding a fast T2 mapping method without errors caused by indirect echoes. Difficulties in the precise diagnosis of bronchial cancers in women. Editorial: Role of Proteins and Peptides in the Virulence and Pathogenesis of Human and Plant Pathogens - PART II. Simple positive and negative ions together with uncharged species of the same size are used as crude models for the hydrophilic and hydrophobic groups of a protein. BMI-1 is involved in cellular processes such as DNA repair, proliferation, growth, senescence and apoptosis. The adenovirus E3/19K glycoprotein forms a tight complex with most human and certain mouse MHC class I allomorphs, retaining them in the endoplasmic reticulum by virtue of its cytosolic carboxyl terminal amino acids.

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Monitoring waste metal pollution at Ganga estuary via the East Calcutta Wetland areas. Participants not only demonstrated post-training improvements in localization accuracy for broadband noises presented in the same set of positions used during training, but also for stimuli presented in untrained locations, for monosyllabic speech sounds, and for stimuli presented in reverberant conditions. The efficacy and safety of a monophasic hyaluronic acid filler in the correction of nasolabial folds: A randomized, multicenter, single blinded, split-face study. Using a degenerate RT-PCR-based screening method, we isolated the homeobox gene, Gbx1, from the shank skin of 13-day-old chick embryos. Templated nanopores for robust functional surface porosity in poly(methyl methacrylate). This method relies on a thermally responsive elastin-like polypeptide (ELP) tag, where the tagged protein is precipitated using a mild temperature shift.

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Impact of emotionality on memory and meta-memory in schizophrenia using video sequences. Acute renal failure in Congolese children: a tertiary institution experience. Between January 2004 and August 2007, we treated 23 patients with complex urogenital fistulae. This contrasting pattern suggests that there is little overlap in resource use of freshly deposited bloom material between Marenzelleria and the native species but it is likely that interference competition acts to dampen resulting community biomass. There was no significant association between presence and numbers of 16S rRNA gene of B. Our data indicate that groups of proteins shuffle from detergent-soluble to detergent-resistant membrane microdomains during maturation, supporting a model in which the modulation of the phagosome functional properties involves an important reorganization of the phagosome proteome by the coordinated spatial segregation of proteins. This analogy is extended to include the effects of the initial composition fluctuations in order to improve its agreement with experimental data in the small wave vector range. Rearrangements in the KcsA cytoplasmic domain underlie its gating. Acute promyelocytic leukaemia, an uncommon and devastating subtype of leukaemia, is highly prevalent in Latin American populations. Information on fractures was obtained, including number of fractures over participant lifetime, age when fractures occurred, location, and cause.

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Adrenomyeloneuropathy is an X-linked disease caused by defects in the ABCD1 gene, which encodes the ALD protein (a peroxisome membrane transport protein). Supervised levothyroxine absorption test is a useful tool in the diagnostic workup for supposed pseudomalabsorption. Incomplete androgen insensitivity syndrome: partially masculinized genitalia in two patients with absence of androgen receptor in cultured fibroblasts. The 2DX robot: a membrane protein 2D crystallization Swiss Army knife. Furthermore, decreased interleukin-6, C-reactive protein, monocyte chemoattractant protein-1, resistin, and malondialdehyde, as well as enhanced leptin levels were detected in HDL-treated mice. Bicycle-related head injuries in South Carolina children: what can we do to prevent them?. Between February is mometasone furoate an antibiotic 2006 and February 2010, 199 consecutive evaluable patients were recruited for this prospective randomized trial. Progesterone and estradiol receptors in the cytosol of the human uterine artery. Although a conceptually simple process, there are several nuances that have been reported in the literature, including transient effects on plate mechanical properties, memory effects, differences between wet and dry heating, and others. Outcome of combined unicompartmental knee replacement and combined or sequential anterior cruciate ligament reconstruction: a study of 52 cases with mean follow-up of five years.

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The expression of Klotho and cell senescence (senescence-associated beta-galactosidase: SA-beta-gal) was detected by immunohistochemistry. Estimation of MECVF relies on quantification of the T1 relaxation time after contrast enhancement, which can be sensitive to equilibrium transcytolemmal water-exchange. The key features of KBIS are to provide a simple search, gallery (photographs), and community to lead the participation of numerous non-experts, especially amateur bird watchers. In this study, a microelectromechanical system (MEMS) two-dimensional (2D) wind direction and wind speed sensor consisting of a square heating source and four thermopiles was manufactured using the heat detection method. Estimating Plasmodium falciparum transmission rates in low-endemic settings using a combination of community prevalence and health facility data. One difficulty in examining LHPA function in macaques may be the confounding effects of cycling ovarian steroids that are known to modulate LHPA activity. Nanostructuring of titania thin films by a combination of microfluidics and block-copolymer-based sol-gel templating. Assay of Lpro activity on a fluorescent hexapeptide substrate showed that Lpro, in contrast to papain, was highly sensitive to increases in the cation concentration and was active only across a narrow pH range. The nationwide incidence of hypospadias in children younger than 3 years in Taiwan is similar to that reported in previous studies.

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Presynaptic cell dependent modulation of inhibition in cortical regions. With computed tomography, hypoxic/ischaemic lesions were represented by areas of decreased density and haemorrhagic lesions by areas of increased density. For microvessels with diameters below approximately 40 microns, the resulting flow resistances are markedly higher and show a stronger dependence on hematocrit than previously estimated from measurements of blood flow in narrow glass tubes. To determine clinical characteristics and rate of ocular complications in patients with Vogt-Koyanagi-Harada disease (VKH). A cross sectional study was conducted in rural areas of Udupi taluk between September 2007 and October 2008 among 150 rural practitioners. Their mother had microcephaly, hypertelorism, prominent columella, broad nasal bridge, wide mouth, high palate, malaligned teeth, and clinodactyly of lanoxin drug the fifth fingers.

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The final outcome was the place of stay (or death) 180 days after ICU admission. For aquatic prey, defences are induced by chemical cues from predators (kairomones) and injured prey (alarm cues). An important convergence point involved in the signal transduction pathways of many different growth factors, hormones, and cytokines are the p42 and p44 serine/ threonine kinases called either MAP kinases (mitogen-activate protein kinases) or ERK 1 and ERK 2 (extracellular regulated kinases) (2-4). A more direct measurement of implant capsule contracture is needed for the laboratory study of this phenomenon. actinomycetemcomitans in the subgingival plaque of patients with aggressive periodontitis and controls among Sudanese high-school students. Covalently linked vancomycin dimers have attracted a great deal of attention among researchers because of their enhanced antibacterial activity against vancomycin-resistant strains. Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus. A comparative study of ethylvinyl and trifluoroethylvinyl ethers. Evaluation of increase of streptomycin-resistant tubercle bacilli in primocultures and subcultures based on examinations carried out from 1954 to 1955. Morphological, physiological and biochemical study of a new species of Clostridium: Cl.

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Assess the risk factors to which home-based caregivers are exposed. Prompt recognition of the transient neonatal hyperammonaemia syndrome is important because its prognosis is much better than that of the primary urea cycle defects presenting in the neonatal period. Diagnostic EUS allows previously unidentified NETs to be localized. The costs of rehabilitation and care were substantially lower for PCDIR. Inclusion of the carboxy-terminal domain of the core protein modifies the core assembly pathway such that the resultant particles have an irregular outline. We suggest that these patterns were influenced by recent increases in size of human populations, which favored the accumulation of advantageous variants at different loci. Excitotoxic lesions of the rostral thalamic reticular nucleus do not affect the performance of spatial learning and memory tasks in the rat. Many methods are used to detect urethral Neisseria gonorrhea (NG) infection among asymptomatic men who have sex with men (MSM).

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The results of the present investigations draw attention to the possible way of receptor alteration via breastmilk. Compared to conventional time-triggered sampling, it leads to muchbetter QoC in WCSs operating in dynamic environments. Distinguishing focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional myocardial strain using two-dimensional speckle tracking echocardiography: comparison with multislice CT. Biological relationship between seminoma and teratoid tumor of testes, differential diagnostic problems and prognosis. A Plastid-Localized Pentatricopeptide Repeat Protein is Required for Both Pollen Development and Plant Growth in Rice. Here we show that Bothrops moojeni crude venom presented a killing effect in vitro against Leishmania spp. Maternal DRI of HbV had no obvious side effects on the pregnant mother or on fetal development.

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The impact of MCAT intervention efforts on medical student acceptance rates. Patients in the PK-TURBT and HoL-TURBT groups had less catheterization and hospitalization time than those in the CM-TURBT group, and there were no significant differences in each risk subgroup as well as the overall recurrence rate among the CM-TURBT, PK-TURBT and HoL-TURBT groups. The process integrates MetaMap with the open-source GATE framework. Pathomechanism of thrombocytopenia and anaemia which frequently occur in patients with malaria is of a complex origin. The most common type of case reports concerned women, employed in non-qualified nursing occupations, and sick listed due to mental disorders. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse model of dry skin. In addition, the classical methods for detecting viral contaminations in foods are summarized.

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