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Nuvigil (Armodafinil)

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Nuvigil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve vigilance in air traffic controllers. Nuvigil is approved by the U.S. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea.For narcolepsy and obstructive sleep apnea, Nuvigil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of Nuvigil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.

Other names for this medication:
Armod, Armodafinil, Biryth, Waklert

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Also known as: Armodafinil


Nuvigil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Nuvigil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder.

It is not known how Nuvigil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Nuvigil is usually given for up to 12 weeks. Follow your doctor's instructions.

Nuvigil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.

If you are taking Nuvigil to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.

Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and Nuvigil may be necessary to best treat your condition.

Nuvigil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.

Taking this medication does not take the place of getting enough sleep. Talk with your doctor if you continue to have excessive sleepiness even while taking Nuvigil.


When a person takes too much Nuvigil, overdose symptoms may include unusual bruising or bleeding, nausea, diarrhea, and chest pain. Specific effects will be based on certain factors. If the Nuvigil overdose was recent, healthcare providers may give certain medicines, place a tube in the stomach to pump the stomach, or treat the symptoms that occur as a result of the overdose.


Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Nuvigil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Nuvigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Nuvigil may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid other dangerous activity until you know how this medication will affect your level of wakefulness.

Avoid drinking alcohol while taking Nuvigil.

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Neuroradiologic picture of cerebral vasculitis in rheumatoid arthritis. Aberrant expression of SEMA3A and its receptor NRP1 might be involved in the development of tongue cancer and might be useful prognostic markers in this tumour type. The most important risk factors for asthma in the South Bronx pediatric population are Hispanic ethnicity, family history of asthma, and exposure to tobacco smoke. Their values apparently shifted against the regression line clozaril dosage chart compared to data from patients with a normal HPT function. Bipolar disorder (BD) is a progressive psychiatric disorder characterized by recurrent changes of mood and is associated with cognitive decline. The patient underwent an amputation at the distal third of the forearm. Here we report a novel transcriptional cooperation between GATA factors and cJUN on the mouse Star and human STAR promoters in MA-10 Leydig cells. The total genetic length varied according to the pedigree, from 1797 to 2149 cM. Upon prolonged administration of high-salt-containing diet, DS rats develop systemic hypertension, and as a consequence they develop left ventricular hypertrophy, followed by heart failure.

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Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats. Our results led us to consider that LDH and LDH5 isoenzyme positivity is associated with type II breast cyst fluids, suggesting that it does not reflect a higher transformation risk, but rather that is a consequence of cyst evolution and of its lining wall. The lesions were classified by two independent observers into four distinct histological groups based on different cell types in the inflammatory infiltrate and formation of granulomata. An axial domain of HOM/Hox gene expression is formed by morphogenetic alignment of independently specified cell lineages in the leech Helobdella. Parameters should include measures of respiratory mechanics, oxygenation, and ventilation. The accuracy of multidetector computed tomography (MDCT) for detecting coronary disease has not been determined, and little information is available regarding the performance of MDCT in patients undergoing dialysis. Impact of diabetes and hyperglycemia on survival in advanced breast cancer patients. Liver failure is commonly encountered in the critically ill, septic patient. Differential frequency-dependent regulation of transmitter release by endogenous nitric oxide at the amphibian neuromuscular synapse. We evaluated colorectal resections initiated with open and minimally invasive approaches, and compared reported risk-adjusted and price-standardized 30-day episode payments and their components.

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Beneficial effects of treadmill training in experimental diabetic nerve regeneration. Multidrug resistance genes, including bla(KPC) and bla(CTX)-M-2 how many mg of pepcid can i take while pregnant , among Klebsiella pneumoniae isolated in Recife, Brazil. To identify an optimal brief version of the Alcohol Use Disorders Identification Test (AUDIT) and to evaluate its effectiveness as a screening test for problem drinking (PD), alcohol use disorders (AUD) and alcohol dependence (AD). The utility of joint sensitivity and specificity curves applied to a diagnostic test. Melatonin treatment significantly depressed PRL concentrations but did not affect the length of the estrous season in Persian gazelles, suggesting that the reproductive cycle was entrained by an endogenous rhythm. Statistical data on blastomas observed during the decade from 1945 to 1954. These results identify a novel signaling pathway that links NO and Src family kinases to cancer cell invasion and metastasis. Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography. A similar plateauing of such elevated titer also occurred in 147-day-old, irregularly cycling females fed only cholesterol as the dietary sterol. The incidence of medical failure for prolactin (PRL)-secreting pituitary tumours is not well known.

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