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Paxil (Paroxetine)

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Paxil is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of panic disorder, anxiety, and obsessive-compulsive disorder.

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Also known as: Paroxetine


Paxil CR is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Paxil CR is used to treat depression, including major depressive disorder.

Paroxtine is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause. Brisdelle is not for treating any other conditions.


Take Paxil exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Swallow the Paxil CR extended-release tablet whole and do not crush, chew, or break the tablet.

Shake the Paxil oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using Paxil suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

Detailed Paxil dosage information


If you overdose Generic Paxil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Paxil overdosage: seizures, confused mental state, coma, tremor, nausea, blurred vision, retching, sweating, decreased urination, aggression, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Paxil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Paxil if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine.

Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Paxil you must wait at least 14 days before you start taking an MAO inhibitor.

To make sure Paxil is safe for you, tell your doctor if you have:

heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; narrow-angle glaucoma; or low levels of sodium in your blood.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant such as Paxil during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

You should not breastfeed while using this medicine.

Paxil is not approved for use by anyone younger than 18 years old.

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The combination treatment with vandetanib, cisplatin, and radiation was superior to the rest of treatments (including the double combinations) in antitumoral effects, prolonging survival, decreasing cervical lymph node metastases in vivo. Cardiotoxicity of a non-pegylated liposomal doxorubicin-based regimen versus an epirubicin-based regimen for breast cancer: the LITE (Liposomal doxorubicin-Investigational chemotherapy-Tissue Doppler imaging Evaluation) randomized pilot study. Thus, there is a need for nursing interventions to improve the postoperative experience for patients and families. This article has been withdrawn at the request of the author(s) and/or editor. The TMG flap is a good technical option, comparable to abdominal flaps, for patients with small or medium sized breasts which require reconstruction with autologous tissue. There is a significant increase in wound complications in distal fibular fractures treated with a locking compression plate. Background: Better understanding the molecular mechanisms responsible for the genesis and progression of colorectal cancer would help advance the novel therapeutics.

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Outcomes in Patients Treated with a Novel, Simple Method for Hemostasis of Dermal Avulsion Injuries. The use of these techniques has identified differences in the in vitro replicative capacities of a virulent strain and an avirulent strain of R. Synthetic HA ceramic materials are limited in being able to serve as analogs of bone mineral for use as implants to facilitate bone regeneration. Our in vitro findings were recapitulated in a transgenic mouse model carrying Hfe H67D, the mouse equivalent of the human H63D mutation. If a creche was available at place of work, half the women surveyed said they would breast-feed for longer.

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Quantitative analysis of heart rate variability in patients with absence epilepsy. I will outline the progress and highlight challenges and areas that can be further explored perfecting the personalized health care. Furthermore, the immediate metabolite of dimethylfumarate, monomethylfumarate, leads to direct modification of the inhibitor of nuclear factor (erythroid-derived 2)-related factor 2, Kelch-like ECH-associated protein 1, at cysteine residue 151. This review of published cases is of equal interest to both pathologists and otorhinolaryngologists. Similarly, the addition of dihydrotestosterone (DHT) to androgen-deprived LNCaP cells re-established cell proliferation, through an androgen receptor/PI3K/Akt dependent stimulation of SphK1, and inhibition of SphK1 could markedly impede the effects of DHT. Late potentials analysis in patients with malignant ventricular arrhythmia. Left ventricular aneurysm following myocardial infarct with normal coronary angiography. Experimental hyperglycemic states not primarily due to a lack of insulin. Inhibition of bovine brain microtubule assembly in vitro by stypoldione.

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In an attempt to improve the detection of low quantities of HPV DNA signals revealed by FISH, laser scanning confocal microscopy (LSCM) and quantitative microscopy with an intensified charge coupled device (CCD) camera were used. Clinically diagnosed depression and self-rated depressive state: prognostic ability of cardiac event for patients after myocardial infarction. Furthermore, these factors may share synergistic interactions, which could contribute to the process of liver fibrosis. However, the rather large number of FN observed precludes the use of the UF-100 as a routine screening method to exclude urine samples from culture. The author adopted several diagnostics tests to select the best estimator to overcome econometric problems faced in presence of the past and future cigarette consumption (suspected endogenous variables). constellatio mycorrhizae from those of the Tuber spp., we determined the morphological and bio-molecular characteristics of P. Cyclosporine and the reversibility of chronic vascular rejection. The resulting C-8 ester functionality provides a handle for the synthesis of defucogilvocarcin V as well as some C-8 analogues from a common late-stage intermediate. Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing. We show that the two diversity measures impact on invasibility via distinct and additive mechanisms.

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On the other hand, the real impact of tobacco products on carcinogenesis seems not yet to be fully realized. The preserved cortical network may offer an additional motor rehabilitation approach for people with SCI. No metastases were detected in mice carrying either wtVEGF or mutant VEGF expressing tumors. Multinational validation of the Composite International Diagnostic Interview (CIDI). An entropically efficient supramolecular inhibition strategy for Shiga toxins. pylori co-culture upregulated AQP3 expression in human gastric adenocarcinoma cells in vitro via the extracellular signal-regulated kinase signaling pathway. A large proportion of the medical record currently available in computerized medical information systems is in the form of free text reports. Inadequate supply of the essential trace element selenium (Se) has been associated with predisposition for, or manifestation of, various human diseases such as Keshan and Kashin-Beck disease, cancer, impaired immune function, neurodegenerative and age-related disorders and disturbances of the thyroid hormone axis. UK Renal Registry 19th Annual Report: Chapter 12 Multisite Dialysis Access Audit in England, Northern Ireland and Wales in 2015 and 2014 PD One Year Follow-up: National and Centre-specific Analyses. The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites.

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Twenty-seven fragments of the LSC region of Vitis vinifera cpDNA were amplified and then digested with HinfI and TaqI restriction enzymes. Bleeding controlled by compression was the most common early and late complication. To assess retinal nerve fiber (RNFL) thickness change in glaucoma patients after glaucoma surgery. An esophageal probe (EP) capable of measuring endoesophageal temperature (ET) was positioned before starting the procedure. For HMX, neither bioremediation nor phytoremediation was found to be useful in reducing the concentration within the experimental period.

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Numerical modeling shows that dynamic permeability responses to magmatic fluid expulsion can stabilize a front of metal precipitation at the boundary between lithostatically pressured up-flow of hot magmatic fluids and hydrostatically pressured convection of cooler meteoric fluids. Increased type I MHC was found, except for in GG in old and middle-aged rats. Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action. The pivotal phase II and III trials of adjunctive clobazam are reviewed together with its postulated mode of action, pharmacokinetics and drug interaction profile. Analysis showed that sulfates are the main conjugates in urine, with the exception of isoferulic acid, which minipress medication mental health is mainly glucuronidated. Fetal genitourinary anomalies--a pictorial review with postnatal correlation. Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi). Although emotional functioning is impaired in children with autism, it is unclear if this impairment is due to difficulties with facial expression, autonomic responsiveness, or the verbal description of emotional states.

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The Institutional Review Board approved this retrospective study and waived the informed consent requirement. The hypothesis of this subgroup analysis was that lumbar fusion or particular patient characteristics, such as obesity, would render patients with lumbar stenosis more susceptible to reoperation at the index or adjacent levels. Mental health and risk behavior of married adult HIV/AIDS subjects derived from paid blood donation in the rural of Anhui Province. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. CaPSURE collects approximately 1,000 clinical and patient-reported variables, in over 13,000 men that are enrolled. The intramyocardial dissecting hematoma might appear as a component of the rupture during the evolution process. Control was re-established with an increased dose of prednisolone. This work aimed to study self-rated health in relation to social capital, socioeconomic status, lifestyle and comorbidity in immigrants from Iraq - one of the largest non-European immigrant group in Sweden today - and to compare it with the self-rated health of native Swedes.

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Those with abnormal echocardiograms were referred for a paediatric consultation, with hospital-based echocardiography if required for the clarification of diagnoses and further management. An increase was also noted in plasminogen activator inhibitor type-1 (PAI-1) mRNA levels (2.7-fold), but none was noted in uPA levels. Semen volume was greatest how many mg of tramadol is safe to take in the summer (P less than 0.01) but both the concentration (P less than 0.01) and the total number of spermatozoa per ejaculate (P less than 0.05) were highest in the autumn. Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death. This is a report of a penoscrotal incarceration by four closed steel rings, treated in Northern Ireland with a few minor points reiterated.

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Notch signaling was shown to negatively modulate the stability of neurites and connections in postmitotic primary neurons. Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families. Amyloidosis: its clinical and pathologic manifestations, with a report of 12 cases. Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene. nezarae at all combinations of temperature and RH and this may partially explain the seasonal pattern of occurrence of adult parasitoids in the field previously observed. A slow increase in the temperature of the nutrient solution provoked a 10/min FHR increase pro every 1 degrees C change from 32 to 38 degrees C, and this change did not depend on weight and age of the hearts and the basic FHR. Although 18-oxocortisol was one-third as active as 11-deoxycorticosterone in this assay, it was a more potent mineralocorticoid at the same total plasma concentration because of its lower affinity for corticosteroid-binding globulin.

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Bilateral pneumothorax during transoral incisionless fundoplication. Random-effects models were used to estimate the summary relative risk (RR) of MetS with LTPA. Maxillo-malar osteotomy permitting the reflection of the osteotomized segment pedicled to the cheek after a Weber-Fergusson type cutaneous incision is the method that for the authors gives the best visibility. In 21 consecutive operations the insertion of the lumbrical muscle was abnormal. Ochroconis gallopavum infection in a lung transplant recipient: report of a case. Clinical phenotypes of a juvenile sibling pair carrying the fragile X premutation. Therefore, it can be concluded that weight loss behavior of these wrestlers should be changed from using dehydration methods to using gradual methods of weight loss such as fat reduction methods. Recombinant rat MBP-A bound recombinant human soluble CD14 in a concentration-dependent manner. Two cationic liposome formulations were used, one composed of a mixture of dioleoyl trimethylammoniopropane and cholesterol (DOTAP:Chol) and the other a pH sensitive formulation constituted of DOTAP, Chol, Dioleoyl phosphatidylethanolamine (DOPE) and cholesteryl hemisuccinate (CHEMS). Our previous report implicated skeletal muscle and liver insulin resistance in people with type 1 diabetes, but this occurred independently of generalized, visceral, or ectopic fat.

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This study showed clinical improvement in patients with knee pain who were managed with Cox flexion distraction decompression applied to the knee. Improving prevention of HIV infection in adolescents and young adults and in treating those who become HIV infected is crucially important. These large forces may plastically deform the mud, allowing the worm to build a semi-permanent burrow. This paper reports a method for highly enantioselective Diels-Alder reaction with an acetylene equivalent to produce chiral-bridged dienes. Synergistic interaction was demonstrated between female sex and nonwhite race, greatest mortality being in nonwhite females through age 74. These results suggest that it is possible to dry toad venom by heating at high temperature for several hours. The abundance of several plasma metabolites varies according to the levels of parasitemia in patients with P. This study shows that several individual-level and site-level factors are associated with blood lead levels among bridge painters, including lead exposure through inhalation and possible hand-to-mouth contact, personal behaviors such as smoking on site, respirator fit testing, and work site conditions such as the use of better containment facilities.

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