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Xeloda (Capecitabine)
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Xeloda

Xeloda is a type of chemotherapy drug you might have it on its own or with other types of chemotherapy drugs. It is also called Xeloda. It is a treatment for several types of cancer. It is a tablet you take twice a day morning and evening.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

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Micardis, Neoral, Danocrine, Imuran, Pepcid, Tensaar, Biocard, Almix, Metacortil, Metrosil, Sinozol, Kamagra, Venlift, Bisoce, Azicid,

Also known as: Capecitabine

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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Reviews panels on the prevention of preterm birth (PTB) conducted by the Office of the Surgeon General and the Eunice Kennedy Shriver National Institute of Child Health and Human Development made numerous novel recommendations for research on the assessment of risk factors for PTB and the development of personalized, specific interventions for the prevention of PTB. Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion. I studied the vocal/auditory aspect of this ability to look at operational differences between the two members of a recognition dyad. We recruited 126 adults from six rural Indiana counties who participated in study activities in the following order: 1) a pre-focus group demographic, knowledge and attitude survey, 2) a focus group for discussing the feasibility of a telephone-administered hearing screening, 3) a post focus group attitude survey and 4) hearing was screened using an audiometer and self-assessment scale. Combined clopidogrel and aspirin overcome single drug resistances, are safe for bleeding and improve venous graft patency.

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We demonstrate the successful anesthetic management of a patient with LAM undergoing a lengthy suboccipital craniotomy for a posterior fossa mass. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. During rice milling and processing, broken kernels are inevitably present, although to date it has been unclear as to how the presence of broken kernels affects rice hydration and cooked rice texture. Two expressed soybean genes with high sequence identity to tomato Pti1 kinase lack autophosphorylation activity. Applying a PET-CT scan only in asymptomatic patients is probably as effective and more cost-effective. Smoking cessation for substance misusers: A systematic review of qualitative studies on participant and provider beliefs and perceptions. From the Veterinary Chief Inspection of Public Health and the Board of the Veterinary Service.

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Report of a remnant tubal pregnancy after cloacal malformation repair. Germline genetic abnormalities might contribute to the susceptibility of some patients to develop T-ALL. These include the influence of RNA modifications on activity-induced RNA structure states, RNA editing and RNA localization, and how qualitative state changes in RNA increase the functional diversity and information-carrying capacity of RNA molecules. Here we review the development of functional neuroimaging as a research tool and recent neuroimaging studies relating to food reward. The consequences of penile foreign bodies can be mild or very severe, resulting in penile amputation. Final radiographs were compared with preoperative x-rays to investigate the effect of possible ulnar impingement syndrome (convergent instability).

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Factors associated with prostate cancer screening: a population-based study. Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients. However, the binding activity of MBP-Rep68 delta to DNA does not appear to correlate with trs endonuclease activity. It is best managed in an intensive care unit where continuous assessment may enable rapid detection of clinical deterioration and allow appropriate treatment to be instituted. Also, verbal prompts by themselves resulted in a low probability of self-initiated responding. Excitatory effects of histamine on the electrical and mechanical responses were reduced by application of tetrodotoxin, prazosin, phentolamine or guanethidine.

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At 5 weeks bronchoscopy showed complete healing of the dehiscences with granulation. Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding. Increasing evidence suggests that root extracellular proteins are involved in interactions between roots and their soil environment. Further evaluation of lung cancer risk after ER(-) breast cancer may identify women at high risk for this fatal malignancy. The experiments were carried out in cats anaesthetized with chloralose and urethane. In-depth interviews were conducted with fourteen women, between 4 months and 7 years after prophylactic oophorectomy. Potentiation of the action of insulin by hypoglycemic sulfonamides. Transurethral radiofrequency thermal ablation of prostatic tissue: a feasibility study in humans. Hypoxic brain damage after prolonged cardiac arrest during anesthesia--changes in CT and serum NSE concentration. To assess cholera recognition and treatment by US health care workers in the largest can you have alcohol with bactrim ds cholera outbreak in the United States this century.

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We also describe how mitochondria can regulate longevity by ROS-independent mechanisms. Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog. Modest direct associations were identified between estrogen levels and breast cancer incidence among both never and baseline HRT users. Theory development for HIV behavioral health: empirical validation of behavior health models specific to HIV risk. The colon carcinogen 1,2-dimethylhydrazine (DMH) was cultured with rat colon epithelial cells to determine if these cells have the ability to metabolize DMH. Phospholipase D (PLD) is an important enzyme involved in signal transduction, vesicle trafficking and membrane metabolism. Cerebrospinal fluid (CSF) and synovial fluid (SF) were obtained from patients during spinal puncture and athroscopy, respectively. A total of 65 species were collected, among which, polychaeta and mollusk were the dominant groups, Capitella capitata and Nassarius succinctus were the dominant species in spring and winter, respectively. Color-coding of structural images based on the expression level enables a fast visual data analysis in the background of the examined biological system.

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Dosimetric evaluation of a novel high dose rate (HDR) intraluminal / interstitial brachytherapy applicator for gastrointestinal and bladder cancers. This study used qualitative methods and involved 24 in-depth interviews with Chinese immigrants aged 65 or older in Los Angeles. Different bivariate kernel functions for a situation with the low soluble product BaSO(4) and its two reactants BaCl(2) and K(2)SO(4) have been analyzed within this term. For tissue engineering approaches osseous differentiation is performed on 3D scaffolds, but material depending influences promote cellular processes like adhesion, proliferation and differentiation. The time from injury to hospital admission was 1 hour to 14 days. It is shown that the HPLC separation methodology yields accurate, reproducible results devoid of interference from the presence of alpha-methyldopa. We conducted an exploratory study using a high-resolution metabolomics platform that uncovered significant associations between parasitemia levels and plasma metabolites from 150 patients with P. CA19-9 is a promising biomarker for early progression following CRS/HIPEC, whereas CA-125 is associated with shorter survival. This paper reviews some actual facts about celiac disease and focuses on the reported applications of hydrocolloids in gluten-free breads.

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Difficulties in reaching correct bacteriological identification, increased resistance to beta-lactam antibiotics and macrolides and complicated clinical course have contributed to problems in management of cases of infective endocarditis caused by this bacterium. To demonstrate that AO precipitated by oestrogens and characterized by nonfunctional C1-Inh is mediated by BK and to evaluate the occurrence of urticaria in these patients. Interordinal relationships and timescale of eutherian evolution as inferred from mitochondrial genome data. This suggested that particle changes in the submicron range were related to HSV-2 virion structure and had direct impact on biological activity. Accumulating evidence demonstrates that the hypothesis that only B cells arising in fetal or neonatal tissues have the potential to become B-1a cells cannot be true. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. We what medication is comparable to zantac sought to analyze specific preoperative findings to predict mortality, shorter mechanical ventilation, and hemodynamic improvement after PEA. Intraoperative radiotherapy of locally advanced and recurrent rectal cancer. The multidisciplinary approach to the solution of student mental health problems.

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