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Xeloda (Capecitabine)

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Xeloda is a type of chemotherapy drug you might have it on its own or with other types of chemotherapy drugs. It is also called Xeloda. It is a treatment for several types of cancer. It is a tablet you take twice a day morning and evening.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

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Micardis, Neoral, Danocrine, Imuran, Pepcid, Tensaar, Biocard, Almix, Metacortil, Metrosil, Sinozol, Kamagra, Venlift, Bisoce, Azicid,

Also known as: Capecitabine


Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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Reviews panels on the prevention of preterm birth (PTB) conducted by the Office of the Surgeon General and the Eunice Kennedy Shriver National Institute of Child Health and Human Development made numerous novel recommendations for research on the assessment of risk factors for PTB and the development of personalized, specific interventions for the prevention of PTB. Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion. I studied the vocal/auditory aspect of this ability to look at operational differences between the two members of a recognition dyad. We recruited 126 adults from six rural Indiana counties who participated in study activities in the following order: 1) a pre-focus group demographic, knowledge and attitude survey, 2) a focus group for discussing the feasibility of a telephone-administered hearing screening, 3) a post focus group attitude survey and 4) hearing was screened using an audiometer and self-assessment scale. Combined clopidogrel and aspirin overcome single drug resistances, are safe for bleeding and improve venous graft patency.

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Puralpha is a ubiquitous nucleic acid-binding protein which has been implicated in the control of eukaryotic gene transcription. The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patients. The ultraviolet-visible (UV-VIS) spectral features of aqueous solutions of ink particles were dependent on particle size. Percutaneous Transhepatic Cholangioscopic Lithotripsy (PTCSL) is an attractive salvage option for the treatment of recurrent hepatolithiasis. Individuals at risk of (H1N1) influenza A infection are recommended to receive vaccination.

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When hpa1Xoo was transformed into the susceptible cotton line Z35 through Agrobacterium-mediated transformation, the transgenic cotton line (T-34) with an improved resistance to Verticillium dahliae was obtained. Homology modeling suggested that stabilization of the C-20 protosteryl cation by the active-site Phe701 through cation-pi interactions is important for the product outcome between protostadienol and lanosterol. Here we describe construction of recombinant baculoviruses for high-level expression of histidine-tagged rat MKK1 and MKK2, and procedures for production of nearly homogeneous MKK1 and MKK2 fusion proteins, in both inactive and active forms. The ATM kinase directly binds to and phosphorylates KSRP, leading to enhanced interaction between KSRP and pri-miRNAs and increased KSRP activity in miRNA processing. Combining the three serotypes did not seem to affect the antibody responses to individual serotypes, except when given at high dose, where the IgG response to serotype III but not the opsonophagocytic activity was slightly reduced compared to monovalent administration. In all, 90 patients were enrolled in the study, 58 with patent SVGs and 32 with SVGD. The association with a well-differentiated conventional papilloma of the renal pelvis is the noteworthy feature of this case. Fungus-like organisms possess certain morphological features of fungi, such as the hyphal organization of the Oomycota or the spores and reproductive structures inside a fructification of plasmodiophorids (Plasmodiophoromycota) and slime moulds (Mycetozoa). Such mechanism can accommodate the functional diversity among the FNTs, as it may facilitate both, export and import of substrates, with or without proton co-transport.

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Report of a remnant tubal pregnancy after cloacal malformation repair. Germline genetic abnormalities might contribute to the susceptibility of some patients to develop T-ALL. These include the influence of RNA modifications on activity-induced RNA structure states, RNA editing and RNA localization, and how qualitative state changes in RNA increase the functional diversity and information-carrying capacity of RNA molecules. Here we review the development of functional neuroimaging as a research tool and recent neuroimaging studies relating to food reward. The consequences of penile foreign bodies can be mild or very severe, resulting in penile amputation. Final radiographs were compared with preoperative x-rays to investigate the effect of possible ulnar impingement syndrome (convergent instability).

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The incremental prognostic impact on cardiovascular outcomes of assessment of carotid plaque ultrasound characteristics in addition to inflammatory biomarkers remains controversial in coronary artery disease (CAD) patients receiving optimal medical treatment. In addition, participants showed an other-age effect, recognizing White young faces better than White old faces. Legionellae are opportunistic facultative intracellular pathogens with several antigens and toxic components which may function synergistically in contribution to pathogenesis and immunity. Allergens collected from the transwell basal chambers of A20-deficient HT-29 monolayers still conserved functional antigenicity. It is demonstrated that an efficient way of increasing metabolic stability and selectivity of this series is to decrease compound lipophilicity by engineering nondesolvation related attractive interactions with CCR8, as rationalized by three-dimensional receptor models. Although pH and acid output were controlled better with cimetidine than no treatment this was not true for volume of secretion. Relationship between ultrasound and computed tomography is then evaluated on the basis of own experience. Seventy-five patients with biopsy-proven, intermediate, and high- zyrtec allergy 10 mg uses risk prostate cancer underwent preoperative T2-weighted (T2w), dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI at 1.5T. The alimentary tract was reconstructed with interposed ileocolon eight weeks later.

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Factors associated with prostate cancer screening: a population-based study. Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients. However, the binding activity of MBP-Rep68 delta to DNA does not appear to correlate with trs endonuclease activity. It is best managed in an intensive care unit where continuous assessment may enable rapid detection of clinical deterioration and allow appropriate treatment to be instituted. Also, verbal prompts by themselves resulted in a low probability of self-initiated responding. Excitatory effects of histamine on the electrical and mechanical responses were reduced by application of tetrodotoxin, prazosin, phentolamine or guanethidine.

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This is shown by the production of GroELx in Escherichia coli transformed with modified DNA clones lacking P1 and by an enhanced production of a GroELx::beta-galactosidase fusion protein when a portion of groEx containing P2 is linked to the lacZ gene. Whereas there was no difference in reactivity of arterioles to the agonists in rats fed the nonalcohol and alcohol diets for a period of 2-3 wk, there was a significant impairment in reactivity of arterioles to acetylcholine and ADP, but not nitroglycerin, in rats fed the alcohol diet for longer durations. Conventional computed tomography or MRI has been suboptimal in detecting depth of cervical stromal invasion and nodal metastasis.18-Fluorodeoxyglucose PET or integrated PET/computed tomography (thereafter as PET collectively) is valuable for assessing prognosis, treatment response after the completion of concurrent chemoradiation, documented recurrent cervical cancer, and posttreatment unexplained tumor marker elevation. We carried out a computer simulation study to examine how the scalp EEG and the ECoG, as well as the source reconstruction therefrom, employing equivalent current dipole estimation methods, are affected by the insulating ECoG grids. To test this hypothesis, methylseleninic acid (MSeA) and other compounds that could generate methylselenol rapidly were compared with Se compounds that do not generate monomethyl Se, using a well-characterized synchronized TM6 mouse mammary epithelial tumor model in vitro. Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents. This review summarizes the pharmacological properties and the clinical efficacy and safety profile of OTG based on the published literature and unpublished data provided by the manufacturer upon request. Performance on cognitive screening tests, namely Modified Mini Mental state (3MS) exam, Mini Mental state Exam (MMSE) and Functional Rating Scale (FRS) were compared how long does xanax show up on drug test between patients with pure AD and multiple pathology.

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At 5 weeks bronchoscopy showed complete healing of the dehiscences with granulation. Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding. Increasing evidence suggests that root extracellular proteins are involved in interactions between roots and their soil environment. Further evaluation of lung cancer risk after ER(-) breast cancer may identify women at high risk for this fatal malignancy. The experiments were carried out in cats anaesthetized with chloralose and urethane. In-depth interviews were conducted with fourteen women, between 4 months and 7 years after prophylactic oophorectomy. Potentiation of the action of insulin by hypoglycemic sulfonamides. Transurethral radiofrequency thermal ablation of prostatic tissue: a feasibility study in humans. Hypoxic brain damage after prolonged cardiac arrest during anesthesia--changes in CT and serum NSE concentration. To assess cholera recognition and treatment by US health care workers in the largest can you have alcohol with bactrim ds cholera outbreak in the United States this century.

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Cytokines, organized in networks of related peptides with pleiotropic functions, are pivotal humoral mediators of infection and inflammation, and they play an important role in hematopoiesis and autoimmunity. In low concentrations GSH (0.01 and 0.1mM) is a potential NO scavenger in the culture medium. The design involved in PapI and Lrp regulation of the pap operon. The aim of this study was to survey chronic pain patients who were taking opioids for their pain, to determine the incidence of these adverse conditions. We report an interesting case of a 32-year-old male with a clinical history of acute myelogenous leukemia, postallogeneic peripheral blood stem cell transplantation that was found to have chloroma of the right testis. All cases resulted in a gross total resection and no added long-term surgical morbidity. No correlations were found between positive/negative symptoms score and both polymorphisms. Glucose and fructose crystals undergo significant superheating during melting that allows one to study the kinetics of this process. This systematic review synthesizes the qualitative and quantitative studies on the relationship between elder abuse and psychological distress, namely psychological distress as a risk factor and/or a consequence of elder abuse.

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Dosimetric evaluation of a novel high dose rate (HDR) intraluminal / interstitial brachytherapy applicator for gastrointestinal and bladder cancers. This study used qualitative methods and involved 24 in-depth interviews with Chinese immigrants aged 65 or older in Los Angeles. Different bivariate kernel functions for a situation with the low soluble product BaSO(4) and its two reactants BaCl(2) and K(2)SO(4) have been analyzed within this term. For tissue engineering approaches osseous differentiation is performed on 3D scaffolds, but material depending influences promote cellular processes like adhesion, proliferation and differentiation. The time from injury to hospital admission was 1 hour to 14 days. It is shown that the HPLC separation methodology yields accurate, reproducible results devoid of interference from the presence of alpha-methyldopa. We conducted an exploratory study using a high-resolution metabolomics platform that uncovered significant associations between parasitemia levels and plasma metabolites from 150 patients with P. CA19-9 is a promising biomarker for early progression following CRS/HIPEC, whereas CA-125 is associated with shorter survival. This paper reviews some actual facts about celiac disease and focuses on the reported applications of hydrocolloids in gluten-free breads.

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Difficulties in reaching correct bacteriological identification, increased resistance to beta-lactam antibiotics and macrolides and complicated clinical course have contributed to problems in management of cases of infective endocarditis caused by this bacterium. To demonstrate that AO precipitated by oestrogens and characterized by nonfunctional C1-Inh is mediated by BK and to evaluate the occurrence of urticaria in these patients. Interordinal relationships and timescale of eutherian evolution as inferred from mitochondrial genome data. This suggested that particle changes in the submicron range were related to HSV-2 virion structure and had direct impact on biological activity. Accumulating evidence demonstrates that the hypothesis that only B cells arising in fetal or neonatal tissues have the potential to become B-1a cells cannot be true. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. We what medication is comparable to zantac sought to analyze specific preoperative findings to predict mortality, shorter mechanical ventilation, and hemodynamic improvement after PEA. Intraoperative radiotherapy of locally advanced and recurrent rectal cancer. The multidisciplinary approach to the solution of student mental health problems.

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